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      Genistein: Its role in metabolic diseases and cancer.

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          Abstract

          Genistein is an isoflavone present in soy and is known to have multiple molecular effects, such as the inhibition of inflammation, promotion of apoptosis, and modulation of steroidal hormone receptors and metabolic pathways. Since these molecular effects impact carcinogenesis, cancer propagation, obesity, osteoporosis, and metabolic syndromes, genistein plays an important role in preventing and treating common disorders. The role of genistein has not been adequately evaluated in all these clinical settings. This review summarizes some of the known molecular effects of genistein and its potential role in health maintenance and treatment.

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          Author and article information

          Journal
          Crit. Rev. Oncol. Hematol.
          Critical reviews in oncology/hematology
          Elsevier BV
          1879-0461
          1040-8428
          Nov 2017
          : 119
          Affiliations
          [1 ] Department of Bioscience and Biotechnology, Banasthali University, Banasthali, RAJ-304022, India.
          [2 ] Pace Junior College, Mumbai, Maharashtra 400028, India.
          [3 ] Department of Biotechnology, Dravidian University, Kuppam, AP, 517 426, India. Electronic address: mastanmadhav@yahoo.com.
          [4 ] Department of Bioscience and Biotechnology, Banasthali University, Banasthali, RAJ-304022, India. Electronic address: aafroj@banasthali.in.
          Article
          S1040-8428(17)30300-1
          10.1016/j.critrevonc.2017.09.004
          29065980
          88e699f3-8049-4e2e-bbd8-031348ba45bf
          History

          Metabolic diseases,Adipogenesis,Cancer,Genistein,Insulin
          Metabolic diseases, Adipogenesis, Cancer, Genistein, Insulin

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