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      Personalized Prognostic Models for Oncology: A Machine Learning Approach

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          Abstract

          We have applied a little-known data transformation to subsets of the Surveillance, Epidemiology, and End Results (SEER) publically available data of the National Cancer Institute (NCI) to make it suitable input to standard machine learning classifiers. This transformation properly treats the right-censored data in the SEER data and the resulting Random Forest and Multi-Layer Perceptron models predict full survival curves. Treating the 6, 12, and 60 months points of the resulting survival curves as 3 binary classifiers, the 18 resulting classifiers have AUC values ranging from .765 to .885. Further evidence that the models have generalized well from the training data is provided by the extremely high levels of agreement between the random forest and neural network models predictions on the 6, 12, and 60 month binary classifiers.

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          Author and article information

          Journal
          2016-06-22
          Article
          1606.07369
          88f33cd9-0bf0-4feb-bb02-791048cebba6

          http://arxiv.org/licenses/nonexclusive-distrib/1.0/

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          Custom metadata
          28 pages, 3 figures
          stat.AP cs.LG stat.ML

          Applications,Machine learning,Artificial intelligence
          Applications, Machine learning, Artificial intelligence

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