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      The Natural History of Leukocyturia Associated with Indinavir Treatment in HIV+ Individuals

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          Urinary complications observed during indinavir treatment of HIV disease are often attributed to indinavir crystalluria. In a prospective study of urinalysis during the first year of indinavir therapy, 5 of 54 asymptomatic HIV+ individuals presented severe leukocyturia (≧100 cells/HPF) usually accompanying indinavir crystalluria. The clinical course of these 5 individuals, successfully treated for HIV and monitored for an second follow-up year, suggests that recurrence of severe leukocyturia may be an indicator of renal damage, likely tubulointerstitial disease caused by indinavir crystalluria. This is in contrast to the remaining 49 subjects, including those presenting mild leukocyturia, who did not demonstrate any evidence of renal disease. Regular urinalysis is therefore recommended in the clinical management of indinavir-treated individuals to detect early renal damage secondary to indinavir crystalluria and to prevent further renal impairment.

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          Changes in renal function associated with indinavir.

          Indinavir use is associated with a spectrum of renal and urinary tract complications including nephrolithiasis, renal colic and pain without recognizable lithiasis, and a picture of crystalluria-dysuria. A frank nephropathy has not been recognized as part of the spectrum.
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            Variation in incidence of indinavir-associated nephrolithiasis among HIV-positive patients.

            Nephrolithiasis may be an important consequence of indinavir therapy; however little has been published on the variation in incidence between different populations of patients or the possible mechanisms of calculus formation.
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              Ritonavir and renal failure.


                Author and article information

                Am J Nephrol
                American Journal of Nephrology
                S. Karger AG
                December 2000
                22 December 2000
                : 20
                : 6
                : 448-454
                Departments of aMedicine and bPathology, The Montreal General Hospital, Montreal, Que., Canada
                46198 Am J Nephrol 2000;20:448–454
                © 2000 S. Karger AG, Basel

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                Page count
                Figures: 2, Tables: 1, References: 36, Pages: 7
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/46198
                Clinical Study


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