Autochthonous Crimean-Congo Hemorrhagic Fever in Spain.

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Abstract

Crimean-Congo hemorrhagic fever (CCHF) is a widely distributed, viral, tickborne disease. In Europe, cases have been reported only in the southeastern part of the continent. We report two autochthonous cases in Spain. The index patient acquired the disease through a tick bite in the province of Ávila - 300 km away from the province of Cáceres, where viral RNA from ticks was amplified in 2010. The second patient was a nurse who became infected while caring for the index patient. Both were infected with the African 3 lineage of this virus. (Funded by Red de Investigación Cooperativa en Enfermedades Tropicales [RICET] and Efficient Response to Highly Dangerous and Emerging Pathogens at EU [European Union] Level [EMERGE].).

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Journal

Journal ID (iso-abbrev): N. Engl. J. Med.

Title: The New England journal of medicine

Publisher: New England Journal of Medicine (NEJM/MMS)

ISSN (Electronic): 1533-4406

ISSN (Print): 0028-4793

Publication date (Electronic): July 13 2017

Volume: 377

Issue: 2

Affiliations

[1 ] From the Arbovirus and Imported Viral Diseases Unit, Centro Nacional de Microbiología, Instituto de Salud Carlos III (A.N., M.P.S.-S., E.R.A., F.L.), Red de Investigación Colaborativa en Enfermedades Tropicales (A.N., M.P.S.-S., E.R.A., F.L.), High Level Isolation Unit (F.C.-P., M.M.-R., A.M.-Q., E.T., J.C.F., J. Manzanares, O.R.-F., V.M.C., J.R.A.) and Departments of Preventive Medicine (N.G.-A.) and Occupational Health (M.V.F.-D.), La Paz University Hospital, Intensive Care Unit (E.P.-H., A.M.G., L.L.P., D.D.-D., M.A.L.-G.) and Departments of Internal Medicine (B.S.-A.), Emergency (J.L.F.), and Occupational Health (P.D.-J.), Infanta Leonor University Hospital, Epidemiology Area of the Autonomous Community of Madrid (J.A.-M., M.O.G., E.R.-B., L.G.-C.), Intensive Care Unit (E.B.L., E.K.-D.) and Departments of Pathology (J. Menárguez, J. Milla) and Clinical Microbiology and Infectious Diseases (A.F.-C.), Gregorio Marañón University General Hospital, and Instituto de Investigación Sanitaria Gregorio Marañón, Complutense University (J. Menárguez, J. Milla, A.F.-C.) - all in Madrid; and the World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany (P.E., J.S.-C.).

Article

DOI: 10.1056/NEJMoa1615162

PubMed ID: 28700843

SO-VID: 89070ad8-7709-4b4a-be82-3bfb4a2654ab

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