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      Effect of Expansion of Renal Parenchymal Volume on Renal Function

      , , ,

      Nephron

      S. Karger AG

      Renal swelling, Renal compliance

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          Abstract

          Marked increases in renal volume commonly occur in states of acute renal injury such as acute tubular necrosis or transplant rejection. This expansion appears to be due to a marked increase in compliance of the kidney. The present study examined whether compliance-mediated expansion of renal volume above normal impairs renal function. In each of 11 dogs, we compared the volume and function of a collagenase-treated kidney (CK) to the contralateral intact kidney (IK), first under control conditions, then when both kidneys were subjected to the same conditions to increase intrarenal pressure (raised ureteral or renal venous pressure) and then on return of intrarenal pressure toward control levels. The rationale is that since CK compliance exceeds IK compliance, the absolute difference between CK and IK volume is maximized at increased intrarenal pressure but minimized at normal intrarenal pressure. We found that CK and IK function were equal at normal intrarenal pressure. However, at increased intrarenal pressure there was suppression of GFR and sodium and water excretion in CK vs. IK. On return to normal intrarenal pressure, CK and IK function were, once again, equal. We also found that the difference in CK vs. IK volume correlated with the differences in CK vs. IK function. Thus, acute expansion of renal volume above normal impairs renal function.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1978
          1978
          02 December 2008
          : 22
          : 4-6
          : 492-503
          Affiliations
          Department of Medicine and Allen-Bradley Medical Sciences Laboratory, Medical College of Wisconsin, and Milwaukee County Medical Complex, Milwaukee, Wisc.
          Article
          181518 Nephron 1978;22:492–503
          10.1159/000181518
          216943
          © 1978 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 12
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Renal compliance, Renal swelling

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