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      Effect of Expansion of Renal Parenchymal Volume on Renal Function

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      S. Karger AG

      Renal swelling, Renal compliance

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          Marked increases in renal volume commonly occur in states of acute renal injury such as acute tubular necrosis or transplant rejection. This expansion appears to be due to a marked increase in compliance of the kidney. The present study examined whether compliance-mediated expansion of renal volume above normal impairs renal function. In each of 11 dogs, we compared the volume and function of a collagenase-treated kidney (CK) to the contralateral intact kidney (IK), first under control conditions, then when both kidneys were subjected to the same conditions to increase intrarenal pressure (raised ureteral or renal venous pressure) and then on return of intrarenal pressure toward control levels. The rationale is that since CK compliance exceeds IK compliance, the absolute difference between CK and IK volume is maximized at increased intrarenal pressure but minimized at normal intrarenal pressure. We found that CK and IK function were equal at normal intrarenal pressure. However, at increased intrarenal pressure there was suppression of GFR and sodium and water excretion in CK vs. IK. On return to normal intrarenal pressure, CK and IK function were, once again, equal. We also found that the difference in CK vs. IK volume correlated with the differences in CK vs. IK function. Thus, acute expansion of renal volume above normal impairs renal function.

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          Author and article information

          S. Karger AG
          02 December 2008
          : 22
          : 4-6
          : 492-503
          Department of Medicine and Allen-Bradley Medical Sciences Laboratory, Medical College of Wisconsin, and Milwaukee County Medical Complex, Milwaukee, Wisc.
          181518 Nephron 1978;22:492–503
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 12
          Original Paper

          Cardiovascular Medicine, Nephrology

          Renal compliance, Renal swelling


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