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      Anti-rheumatoid arthritic effect of volatile components in notopterygium incisum in rats via anti-inflammatory and anti-angiogenic activities

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          Abstract

          Notopterygium incisum (QH) has been used for the treatment of rheumatoid arthritis (RA), and volatile oils may be its mainly bioactive constituents. The present study was designed to analyze the volatile compounds in QH and to determine the anti-arthritic capacity of Notopterygium volatile oils and the potential mechanism of action. The volatile compounds analysis was conducted by GC-MS. The anti-arthritic capacity test of the volatile oils was conducted on adjuvant-induced arthritis (AIA) rats. The anti-inflammatory property was tested in NO release model in RAW 264.7 cells. Endothelial cells were used to evaluate the anti-proliferative and anti-tube formative effects. 70 compounds were analyzed by GC-MS in the volatile oils. Notopterygium volatile oils weakened the rat AIA in a dose-dependent manner (2, 4, and 8 g crude drug/kg). The NO production by RAW 264.7 was decreased by more than 50% in Notopterygium volatile oils (5, 15, and 45 μg·mL –1) pretreated groups. Notopterygium volatile oils also inhibited EAhy926 cell proliferation and further delayed EAhy926 cell capillary tube formation in a concentration-dependent manner. The anti-NO productive, anti-proliferative, and anti-tube formative effects of Notopterygium volatile oils strongly suggested that the therapeutic effect of QH in AIA might be related to the potent anti-inflammatory and anti-angiogenic capacities of the volatile oils.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 December 2018
          : 16
          : 12
          : 926-935
          Affiliations
          1Shandong Provincial Traditional Chinese Medical Hospital, Affricated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250000, China
          2Center for Drug Safety Evaluation and Research of Zhejiang University, Hangzhou 310000, China
          3State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210000, China
          4Key Laboratory for the Research of Aromatic Chinese Medicine in Yunnan, College of Pharmaceutical Science, Yunnan University of Traditional Chinese Medicine, Kunming 650000, China
          5School of Pharmacy, Xinjiang Medical University, Urumqi 830001, China
          Author notes
          *Corresponding authors: WANG Ting, E-mail: wangt662@ 123456hotmail.com ; LI Fei, E-mail: lifeicpu@ 123456163.com

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30134-1
          10.1016/S1875-5364(18)30134-1
          Copyright © 2018 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 81760745
          Funded by: Major Research Plan of Shandong Province
          Award ID: 2016GSF202041
          Funded by: Yunnan Provincial Department of Education Research Fund
          Award ID: 2017ZDX230
          Funded by: Yunnan Innovation Team of Application Research on TCM Theory of Prevention Disease in Yunnan University of TCM
          Award ID: 2017HC011
          This work was supported by the National Natural Science Foundation of China (No. 81760745), Major Research Plan of Shandong Province (No. 2016GSF202041), Yunnan Provincial Department of Education Research Fund (No. 2017ZDX230), and Yunnan Innovation Team of Application Research on TCM Theory of Prevention Disease in Yunnan University of TCM (No. 2017HC011).

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