9
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Estimation of the toxicity of sulfadiazine to Daphnia magna using negligible depletion hollow-fiber liquid-phase microextraction independent of ambient pH

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The toxicity of ionizable organic compounds to organisms depends on the pH, which therefore affects risk assessments of these compounds. However, there is not a direct chemical method to predict the toxicity of ionizable organic compounds. To determine whether hollow-fiber liquid-phase microextraction (HF-LPME) is applicable for this purpose, a three-phase HF-LPME was used to measure sulfadiazine and estimate its toxicity to Daphnia magna in solutions of different pH. The result indicated that the sulfadiazine concentrations measured by HF-LPME decreased with increasing pH, which is consistent with the decreased toxicity. The concentration immobilize 50% of the daphnids (EC50) in 48 h calculated from nominal concentrations increased from 11.93 to 273.5 mg L −1 as the pH increased from 6.0 to 8.5, and the coefficient of variation (CV) of the EC50 values reached 104.6%. When calculated from the concentrations measured by HF-LPME (pH 12 acceptor phase), the EC50 ranged from 223.4 to 394.6 mg L −1, and the CV decreased to 27.60%, suggesting that the concentrations measured by HF-LPME can be used to estimate the toxicity of sulfadiazine irrespective of the solution pH.

          Related collections

          Most cited references25

          • Record: found
          • Abstract: found
          • Article: not found

          Modes of action in ecotoxicology: their role in body burdens, species sensitivity, QSARs, and mixture effects.

          In contrast to the general research attitude in the basic sciences, environmental sciences are often goal-driven and should provide the scientific basis for risk assessment procedures, cleanup, and precautionary measures and finally provide a decision support for policy and management. Hence, the prominent role of mechanistic studies in ecotoxicology is not only to understand the impact of pollutants on living organisms but also to deduce general principles for the categorization and assessment of effects. The goal of this review is, therefore, not to provide an exhaustive coverage of modes of toxic action and their underlying biochemical mechanisms but rather to discuss critically the application of this knowledge in ecotoxicological risk assessment. Knowing the mechanism or, at least the mode of toxic action is indispensable for developing descriptive and predictive models in ecotoxicology. This review seeks to show the crucial role of target sites, interactions with the target site(s), and mechanisms for an adequate and efficient ecotoxicological risk assessment. Emphasis in the discussion is on target effect concentrations (or target occupancy), species selectivity and species sensitivity, time perspective of effect studies, Quantitative Structure-Activity Relationships (QSAR), and mixture toxicity. A particular focus of this review is on multiple mechanisms. Although the illustrative examples were mainly taken from studies in aquatic ecotoxicology, the proposed conceptual approach is also in principle applicable and even particularly useful for soil and sediment systems. Recommendations for further research and developments include the use of internal effect concentrations and target site concentrations in site-specific risk assessment and as a mixture toxicity parameter as well as general considerations for the derivation of mechanistically meaningful QSAR and other predictive models.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Acute and chronic toxicity of veterinary antibiotics to Daphnia magna.

            The acute and chronic toxicity of nine antibiotics used both therapeutically and as growth promoters in intensive farming was investigated on the freshwater crustacean Daphnia magna. The effect of the antibiotics metronidazole (M), olaquindox (OL), oxolinic acid (OA), oxytetracycline (OTC), streptomycin (ST), sulfadiazine (SU), tetracycline (TC), tiamulin (TI) and tylosin (TY) was tested in accordance to the ISO (1989) and OECD (1996) standard procedures. The acute toxicities (48-h EC50 value, mg/l) in decreasing order were OA (4.6), TI (40), SU (221), ST (487), TY (680) and OTC (approximately 1000). NOECs were 340 mg/l for TC and 1000 mg/l for M and OL. Toxic effect on reproduction occurred generally at concentrations, which were one order of magnitude below the acute toxic levels. The chronic toxicity (EC50 values, mg/l) in the D. magna reproduction test in decreasing order were TI (5.4), SU (13.7), TC (44.8) and OTC (46.2). The NOECs (mg/l) obtained in the reproduction test with OA, ST, TY and M were 0.38 for OA, 32 for ST, 45 for TY and 250 for M. The observed toxicity of OA to D. magna indicates that this substance, which is a commonly used feed additive in fish farms, has a potential to cause adverse effects on the aquatic environment.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Sorption and desorption of sulfadiazine in soil and soil-manure systems.

              Sulfadiazine is a widely used veterinary medicine that has high potential to enter the environment, especially the soil compartment by the application of manure on agricultural land and grass land or by the deposition of dung pats on pasture. Once it reaches the soil environments, it may enter into surface and ground water. Therefore, sorption-desorption behavior of sulfadiazine was studied under laboratory conditions in five different soils varying in their physicochemical properties. A batch equilibration technique was used with initial aqueous solution concentration of sulfadiazine at 5, 0.5, 0.05, and 0.005 microg mL(-1). Sorption-desorption data in soils with and without manure were well fitted with Freundlich model in log form (r(2), 0.99). A sorption-desorption hysteresis effect was apparent in all soils. A significant amount of sulfadiazine was found tightly bound to the soil particles and did not desorb after the desorption process. Moreover, presence of manure enhanced hysteresis effect. Hysteresis coefficient (H) value from soils in absence of manure (0.9-1.0) increased to the soils in presence of manure (0.9-1.8). Soils in the absence of manure showed low level of K(D Sorp.) values ranging from 0.1 to 24.3, suggesting low level sorption of sulfadiazine with appreciable risk of run-off and leaching, and in turn, surface and ground water contamination. However, presence of manure increased the sorption tendency of sulfadiazine significantly (K(D Sorp.), 6.9-40.2). K(D) values pertaining to desorption cycle increased from 1.2-90.4 to 10.4-167.3 in absence and presence of manure, respectively.
                Bookmark

                Author and article information

                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group
                2045-2322
                22 December 2016
                2016
                : 6
                : 39798
                Affiliations
                [1 ]College of Plant Protection, Hunan Agricultural University , Changsha 410128, PR China
                [2 ]Biotechnology Research Center, Hunan Academy of Agricultural Sciences , Changsha 410125, PR China
                [3 ]Southern Regional Collaborative Innovation Center for Grain and Oil Crops in China, Hunan Agricultural University , Changsha, PR China
                [4 ]Collaborative Innovation Center of Farmland Weeds Control , Loudi, Hunan province, PR China
                Author notes
                Article
                srep39798
                10.1038/srep39798
                5177870
                28004779
                8928587c-14ca-4bd0-9e04-18b32bd2ed97
                Copyright © 2016, The Author(s)

                This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

                History
                : 29 April 2016
                : 29 November 2016
                Categories
                Article

                Uncategorized
                Uncategorized

                Comments

                Comment on this article