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      FK506 facilitates chemical kindling induced by pentylenetetrazole in rats

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          Abstract

          To clarify the possible role played by calcineurin in kindling development, we examined the effects of pretreatment with FK506, a selective calcineurin inhibitor, on pentylenetetrazole (PTZ) kindling in rats. FK506 facilitated the speed of kindling induced by repeated administration of 30-mg/kg PTZ, while FK506 did not ameliorate acute seizure manifestations after a single injection of PTZ. Our results suggested that calcineurin might exert an inhibitory effect on PTZ kindling.

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          Author and article information

          Journal
          Epilepsy Research
          Epilepsy Research
          Elsevier BV
          09201211
          September 2001
          September 2001
          : 46
          : 3
          : 279-282
          Article
          10.1016/S0920-1211(01)00284-4
          11518629
          89411ceb-cdb4-406b-969d-44ea41dee029
          © 2001

          https://www.elsevier.com/tdm/userlicense/1.0/

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