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Abstract
To clarify the possible role played by calcineurin in kindling development, we examined
the effects of pretreatment with FK506, a selective calcineurin inhibitor, on pentylenetetrazole
(PTZ) kindling in rats. FK506 facilitated the speed of kindling induced by repeated
administration of 30-mg/kg PTZ, while FK506 did not ameliorate acute seizure manifestations
after a single injection of PTZ. Our results suggested that calcineurin might exert
an inhibitory effect on PTZ kindling.