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      Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease.

      Microbes and Infection / Institut Pasteur

      isolation & purification, Adipocytes, White, parasitology, Adipose Tissue, Aged, Animals, Case-Control Studies, Chagas Disease, Chronic Disease, DNA, Kinetoplast, analysis, Female, Fluorescent Antibody Technique, Heart, Heart Block, Humans, Male, Mice, Mice, Inbred BALB C, Middle Aged, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Trypanosoma cruzi, genetics

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          Abstract

          Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected experimental animals and humans. Here we demonstrate the persistence of the parasite in adipose tissue from of three of 10 elderly seropositive patients with chronic chagasic heart disease. Nine control patients had no parasites in the fat. We also demonstrate that T. cruzi parasitizes primary adipocytes in vitro. Thus, in humans as in mice the parasite may persist in adipose tissue for decades and become a reservoir of infection. Copyright © 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

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          Author and article information

          Journal
          21726660
          3552247
          10.1016/j.micinf.2011.06.002

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