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      Pulmonary Dysfunction Is Common during a Cytomegalovirus Infection after Renal Transplantation even in Asymptomatic Patients: Possible Relationship with Complement Activation

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          Complement and leukocyte-mediated pulmonary dysfunction in hemodialysis.

          During hemodialysis, cardiopulmonary decompensation may appear in uremic patients, possibly caused by plugging of pulmonary vessels by leukocytes. In 34 patients we noted leukopenia (20% of initial levels) during hemodialysis that in 15 was associated with impaired pulmonary function. When we infused autologous plasma, incubated with dialyzer cellophane, into rabbits and sheep, sudden leukopenia and hypoxia occurred, with doubling of pulmonary-artery pressures and quintupling of pulmonary-lymph effluent. Histologic examination showed severe pulmonary-vessel-leukostasis and interstitial edema. The syndrome was prevented by preinactivation of complement but was reproduced by infusions of plasma in which complement was activated by zymosan. Thus, acute pulmonary dysfunction from complement-mediated leukostasis may play a major part in the acute cardiopulmonary complications of cellophane-membrane hemodialysis.
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            Anaphylatoxins: C3a and C5a

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              The biochemistry of complement.

              Current biochemical studies of the complement system are illustrated by description of the activation of complement by the classical pathway after interaction with antibody aggregates. This is described in terms of the structures of the components involved, their assembly and the mechanism of activation.
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                Author and article information

                Journal
                American Review of Respiratory Disease
                Am Rev Respir Dis
                American Thoracic Society
                0003-0805
                August 1987
                August 1987
                : 136
                : 3
                : 580-585
                Article
                10.1164/ajrccm/136.3.580
                2820281
                894e6b0c-6f9c-40d7-8a8e-c91b2ddd2b18
                © 1987
                History

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