For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
1,057
views
85
references
 Top references
cited by
185
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    16
    shares
      391
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Human dendritic cell subsets

      research-article
      Author(s): , ,
      Publication date (Electronic):
      Journal: Immunology
      Publisher: John Wiley & Sons Ltd
      Keywords: dendritic cells, haematology, therapy/immunotherapy

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. Developmental studies indicate that DCs originate independently from monocytes and tissue macrophages. Emerging evidence also suggests that distinct subsets of DCs have intrinsic differences that lead to functional specialisation in the generation of immunity. Comparative studies are now allowing many of these properties to be more fully understood in the context of human immunology.

          Related collections

          Most cited references85

          • Record: found
          • Abstract: found
          • Article: not found

          The nature of the principal type 1 interferon-producing cells in human blood.

          F. Siegal, N Kadowaki, M Shodell … (1999)
          Interferons (IFNs) are the most important cytokines in antiviral immune responses. "Natural IFN-producing cells" (IPCs) in human blood express CD4 and major histocompatibility complex class II proteins, but have not been isolated and further characterized because of their rarity, rapid apoptosis, and lack of lineage markers. Purified IPCs are here shown to be the CD4(+)CD11c- type 2 dendritic cell precursors (pDC2s), which produce 200 to 1000 times more IFN than other blood cells after microbial challenge. pDC2s are thus an effector cell type of the immune system, critical for antiviral and antitumor immune responses.
          Article 0 comments Cited 362 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen.

            Maud Plantinga, Martin Guilliams, Manon Vanheerswynghels … (2013)
            Dendritic cells (DCs) are crucial for mounting allergic airway inflammation, but it is unclear which subset of DCs performs this task. By using CD64 and MAR-1 staining, we reliably separated CD11b(+) monocyte-derived DCs (moDCs) from conventional DCs (cDCs) and studied antigen uptake, migration, and presentation assays of lung and lymph node (LN) DCs in response to inhaled house dust mite (HDM). Mainly CD11b(+) cDCs but not CD103(+) cDCs induced T helper 2 (Th2) cell immunity in HDM-specific T cells in vitro and asthma in vivo. Studies in Flt3l(-/-) mice, lacking all cDCs, revealed that moDCs were also sufficient to induce Th2 cell-mediated immunity but only when high-dose HDM was given. The main function of moDCs was the production of proinflammatory chemokines and allergen presentation in the lung during challenge. Thus, we have identified migratory CD11b(+) cDCs as the principal subset inducing Th2 cell-mediated immunity in the LN, whereas moDCs orchestrate allergic inflammation in the lung. Copyright © 2013 Elsevier Inc. All rights reserved.
            Article 0 comments Cited 345 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon.

              M. Cella, D Jarrossay, F Facchetti … (1999)
              We have identified two cell subsets in human blood based on the lack of lineage markers (lin-) and the differential expression of immunoglobulin-like transcript receptor 1 (ILT1) and ILT3. One subset (lin-/ILT3+/ILT1+) is related to myeloid dendritic cells. The other subset (lin-/ILT3+/ILT1+) corresponds to 'plasmacytoid monocytes'. These cells are found in inflamed lymph nodes in and around the high endothelial venules. They express CD62L and CXCR3, and produce extremely large amounts of type I interferon after stimulation with influenza virus or CD40L. These results, with the distinct cell phenotype, indicate that plasmacytoid monocytes represent a specialized cell lineage that enters inflamed lymph nodes at high endothelial venules, where it produces type I interferon. Plasmacytoid monocytes may protect other cells from viral infections and promote survival of antigen-activated T cells.
              Article 0 comments Cited 304 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Immunology
                Journal ID (iso-abbrev): Immunology
                Journal ID (publisher-id): imm
                Title: Immunology
                Publisher: John Wiley & Sons Ltd
                ISSN (Print): 0019-2805
                ISSN (Electronic): 1365-2567
                Publication date (Print): September 2013
                Publication date (Electronic): 12 August 2013
                Volume: 140
                Issue: 1
                Pages: 22-30
                Affiliations
                Human Dendritic Cell Laboratory, Institute of Cellular Medicine, Newcastle University Newcastle upon Tyne, UK
                Author notes
                Correspondence: Matthew Collin, Human Dendritic Cell Laboratory, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Email: matthew.collin@ 123456ncl.ac.uk

                Senior author: Matthew Collin

                Article
                DOI: 10.1111/imm.12117
                PMC ID: 3809702
                PubMed ID: 23621371
                SO-VID: 8961c8da-162a-4a42-9c67-c85f839b4a32
                Copyright © © 2013 The Authors. Immunology published by John Wiley & Sons Ltd, Immunology, 140, 22-30
                License:

                This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 09 April 2013
                Date revision received : 22 April 2013
                Date accepted : 24 April 2013
                Categories
                Subject: Review Articles

                ScienceOpen disciplines: Immunology
                Keywords: dendritic cells,haematology,therapy/immunotherapy
                Data availability:
                ScienceOpen disciplines: Immunology
                Keywords: dendritic cells, haematology, therapy/immunotherapy

                Comments

                Comment on this article

                scite_

                Similar content391

                See all similar

                Cited by180

                See all cited by

                Most referenced authors1,826

                See all reference authors