2
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Review: Free radicals, antioxidants, and the immune system.

      Annals of clinical and laboratory science
      Animals, Antioxidants, metabolism, Free Radicals, immunology, Humans, Immune System, Lipid Peroxidation

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Oxygen-derived free radicals are important in both natural and acquired immunity. Neutrophil and macrophage phagocytosis stimulates various cellular processes including the "respiratory burst" whereby increased cellular oxygen uptake results in the production of the potent oxidant bactericidal agents, hypochlorous acid and hydroxyl radical. In addition, nitric oxide, a gaseous radical produced by macrophages, reacts with superoxide to form peroxynitrite, also a potent bactericidal agent. Conversely, oxidative stress may be detrimental in acquired immunity by activation of nuclear factor kappa B, which governs gene expression involving various cytokines, chemokines, and cell adhesion molecules, among others. However, antioxidant supplementation essentially reverses several age-associated immune deficiencies, resulting in increased levels of interleukin-2, elevated numbers of total lymphocytes and T-cell subsets, enhanced mitogen responsiveness, increased killer cell activity, augmented antibody response to antigen stimulation, decreased lipid peroxidation, and decreased prostaglandin synthesis.

          Related collections

          Author and article information

          Journal
          10807157

          Chemistry
          Animals,Antioxidants,metabolism,Free Radicals,immunology,Humans,Immune System,Lipid Peroxidation
          Chemistry
          Animals, Antioxidants, metabolism, Free Radicals, immunology, Humans, Immune System, Lipid Peroxidation

          Comments

          Comment on this article