0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Evidence for Oxytocin Synthesis After Electrolytic Destruction of the Paraventricular Nucleus in Rats with Hereditary Hypothalamic Diabetes Insipidus

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The reduced amount of neurosecretory material (NSM) that is stored in pituitary glands of hereditary hypothalamic diabetes insipidus (DI) rats compared with glands of normal rats reflects their oxytocin content, since DI rats are apparently unable to synthesize vasopressin. If oxytocin were synthesized exclusively in the paraventricular nucleus (PVN), then complete destruction of this nucleus in DI rats should result in the disappearance of all NSM from the pars nervosa. Complete bilateral ablation of the PVN in DI rats was achieved with lesioning electrodes in only 2 out of 24 animals, with varying degrees of destruction of the PVN in the remainder. The rats were sacrificed one month after lesioning and the amount of NSM remaining in the pars nervosa was assessed histologically. In general, the results show a rough, direct correlation between the number of PVN cells remaining in the hypothalamus and the amount of stored NSM in the pituitary. Nevertheless, the 2 rats with complete PVN ablation still had pituitary NSM. These results suggest that although the PVN may be primarily concerned with oxytocin synthesis, it does not seem to be the exclusive site of oxytocin production. Considerable amounts of this hormone are apparently synthesized elsewhere, the supraoptic nucleus being the most likely source.

          Related collections

          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1970
          1970
          19 March 2008
          : 6
          : 2
          : 90-97
          Affiliations
          Department of Physiology, Dartmouth Medical School, Hanover, New Hampshire, USA
          Article
          121911 Neuroendocrinology 1970;6:90–97
          10.1159/000121911
          4910834
          © 1970 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 8
          Categories
          Paper

          Comments

          Comment on this article