7
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Spatially and temporally regulated alpha6 integrin cleavage during Xenopus laevis development.

      Biochemical and Biophysical Research Communications
      Animals, Cells, Cultured, Gene Expression Regulation, Developmental, physiology, Integrin alpha6, metabolism, Organ Specificity, Tissue Distribution, Xenopus laevis, embryology

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The alpha6 integrin is essential for early nervous system development in Xenopus laevis. We have previously reported a uPA cleaved form of integrin alpha6 (alpha6p), in invasive human prostate cancer tissue, whose presence correlates with increased migration and invasive capacity. We now report that alpha6 is cleaved during the normal development of Xenopus in a spatially and temporally controlled manner. In addition, unlike normal mammalian tissues, which lack alpha6p, the major form of the alpha6 integrin present in adult Xenopus is alpha6p. The protease responsible for the cleavage in mammals, uPA, is not involved in the cleavage of Xenopus alpha6. Finally, overexpression of a mammalian alpha6 mutant which cannot be cleaved leads to developmental abnormalities suggesting a potential role for the cleavage in development.

          Related collections

          Author and article information

          Journal
          18083114
          2671889
          10.1016/j.bbrc.2007.12.040

          Chemistry
          Animals,Cells, Cultured,Gene Expression Regulation, Developmental,physiology,Integrin alpha6,metabolism,Organ Specificity,Tissue Distribution,Xenopus laevis,embryology

          Comments

          Comment on this article