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      Bridging the Divide: An Onco-Nephrologic Approach to the Monoclonal Gammopathies of Renal Significance

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          Abstract

          The monoclonal gammopathies of renal significance (MGRS) are a group of disorders characterized by monoclonal Ig deposition in the kidney, but are not associated with systemic lymphoma or overt multiple myeloma. The prevailing hypothesis is that the pathogenic paraproteins in MGRS are produced by underlying B cell or plasma cell clones. However, in the MGRS literature, the yield of detecting a clone has been variable, and progression to ESRD is common. Here, we present an “onco-nephrologic” approach to the MGRS disorders by highlighting recent advances in lymphoma and multiple myeloma that can be used in the evaluation and management of these patients.

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          Author and article information

          Journal
          Clin J Am Soc Nephrol
          Clin J Am Soc Nephrol
          clinjasn
          cjn
          CJASN
          Clinical Journal of the American Society of Nephrology : CJASN
          American Society of Nephrology
          1555-9041
          1555-905X
          7 September 2016
          14 July 2016
          : 11
          : 9
          : 1681-1691
          Affiliations
          [* ]Division of Nephrology and
          []Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania
          Author notes
          Correspondence: Dr. Jonathan Hogan, Hospital of the University of Pennsylvania, Division of Nephrology, 3400 Spruce Street, 1 Founders, Philadelphia, PA 19104. Email: jonathan.hogan2@ 123456uphs.upenn.edu
          Article
          PMC5012477 PMC5012477 5012477 03160316
          10.2215/CJN.03160316
          5012477
          27416775
          Copyright © 2016 by the American Society of Nephrology
          Page count
          Figures: 3, Tables: 3, Equations: 0, References: 65, Pages: 11
          Categories
          Mini-Reviews
          Custom metadata
          September 07, 2016

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