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      Autophagy and apoptosis: what is the connection?

      Trends in Cell Biology
      Apoptosis, Apoptosis Regulatory Proteins, metabolism, Autophagy, Proto-Oncogene Proteins c-myc

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          Abstract

          The therapeutic potential of autophagy for the treatment cancer and other diseases is beset by paradoxes stemming from the complexity of the interactions between the apoptotic and autophagic machinery. The simplest question of how autophagy acts as both a protector and executioner of cell death remains the subject of substantial controversy. Elucidating the molecular interactions between the processes will help us understand how autophagy can modulate cell death, whether autophagy is truly a cell death mechanism, and how these functions are regulated. We suggest that, despite many connections between autophagy and apoptosis, a strong causal relationship wherein one process controls the other, has not been demonstrated adequately. Knowing when and how to modulate autophagy therapeutically depends on understanding these connections. Copyright © 2011 Elsevier Ltd. All rights reserved.

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          Author and article information

          Journal
          21561772
          3539742
          10.1016/j.tcb.2011.03.007

          Chemistry
          Apoptosis,Apoptosis Regulatory Proteins,metabolism,Autophagy,Proto-Oncogene Proteins c-myc

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