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      Cryopyrin-associated periodic syndrome in early childhood can be successfully treated with interleukin-1 blockades.

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          Abstract

          Cryopyrin-associated periodic syndrome (CAPS) is caused by a mutation in the NLRP3 gene encoding cryopyrin production. Overproduction of interleukin-1 (IL-1) leads to symptoms that are associated with elevated inflammatory markers, including periodic fever and a rash. We provide a clinical overview of CAPS in children, including three Finnish case studies.

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          Author and article information

          Journal
          Acta Paediatr
          Acta paediatrica (Oslo, Norway : 1992)
          Wiley
          1651-2227
          0803-5253
          Apr 2018
          : 107
          : 4
          Affiliations
          [1 ] Department of Pediatrics, Tampere University Hospital, Tampere, Finland.
          [2 ] Department of Pediatrics, Päijät-Häme District Central Hospital, Lahti, Finland.
          [3 ] Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland.
          [4 ] Department of Pediatrics, Helsinki University Hospital, Helsinki, Finland.
          [5 ] Pediatric Research Centre University of Tampere, Tampere, Finland.
          Article
          10.1111/apa.14217
          29331074
          89b2f8bc-cf4d-47f1-89fe-04acd5a8a44a
          ©2018 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
          History

          Cryopyrin-associated periodic syndrome,Interleukin-1,Periodic fever,Biologics,Children

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