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      Glomerular Annular-Tubular Immune Deposits in Adult Hemolytic Uremic Syndrome



      S. Karger AG

      Hemolytic uremic syndrome, Acute renal failure

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          An 82-year-old female developed hemolytic uremic syndrome (HUS) after a prodromal illness of bloody diarrhea. No specific enteric pathogen was isolated. A renal biopsy performed 5 days after the onset of azotemia revealed typical thrombotic microangiopathy. By electron microscopy, massive annular-tubular deposits admixed with fibrillar fibrin were demonstrated in glomerular capillaries. Immunofluorescent staining of the intracapillary material was positive for IgG, IgM, C<sub>3</sub>, C<sub>1</sub>q and fibrin-related antigens. No evidence of plasma cell dyscrasia, cryoglobulinemia or systemic lupus erythematosus was found, and the patient recovered renal function uneventfully in 2 months. Organized immune deposits appear to have played a role in the pathogenesis of HUS in this patient.

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          Author and article information

          S. Karger AG
          09 December 2008
          : 50
          : 4
          : 371-375
          Department of Nephrology, The Mary Imogene Bassett Hospital, Cooperstown, N.Y.; Department of Pathology, The Presbyterian Hospital, New York, N.Y., and Departments of Medicine and Pathology, Columbia University College of Physicians and Surgeons, New York, NY., USA
          185206 Nephron 1988;50:371–375
          © 1988 S. Karger AG, Basel

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          Page count
          Pages: 5
          Case Report

          Cardiovascular Medicine, Nephrology

          Hemolytic uremic syndrome, Acute renal failure


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