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      A Freeze-Fracture Study on Choriocapillaries in Spontaneously Hypertensive Rats


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          Ultrastructural features of the choriocapillaries of spontaneously hypertensive rats (SHR) were studied by the electron microscope utilizing the freeze-fracture method. Following electron microscopic investigation, morphometric studies were carried out. The fenestrations were observed on the surface of the cleavage plane of the endothelial membrane of the choriocapillaries. On the cleavage plane facing Bruch’s membrane, except for the perinuclear region and the parajunctional zone, the fenestrations were densely distributed and showed a regular arrangement. There was no vesicular opening among these fenestrations. On the cleavage plane facing the scleral front, the fenestrations were fewer than on the cleavage plane facing Bruch’s membrane. Total area measured was 36 μ m<sup>2</sup>in SHR and 39 μ m<sup>2</sup>in controls. The average number of fenestrations per square unit (1 μ m<sup>2</sup>) was 35.0 ± 1.2 and 49.7 ± 3.6, in controls and SHR, respectively, and the difference was significant (p < 0.1%). The average diameter of the fenestrations was 78.8 ± 5.6 nm in SHR and it did not differ much from that in controls (76.6 ± 4.8 nm). The increase of the frequency of the fenestration in the endothelial cells in SHR reveals the increase of vascular permeability of the choriocapillary. In addition to these findings, pore-like structures as large as 0.8 μ m in diameter, were often found on the endothelial cells of the choriocapillaries of SHR. This structure may be considered to be evidence of a pathological increase of the vascular permeability in SHR

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          03 December 2009
          : 11
          : 3-4
          : 177-191
          Department of Ophthalmology, Hirosaki University School of Medicine (Director: Prof. S. Matsuyama), Hirosaki
          265004 Ophthalmic Res 1979;11:177–191
          © 1979 S. Karger AG, Basel

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          : 06 April 1978
          : 30 April 1979
          Page count
          Pages: 15

          Vision sciences,Ophthalmology & Optometry,Pathology
          Freeze-fracture,Spontaneously hypertensive rats,Permeability and hypertension,Fenestration,Choriocapillary


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