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      A Freeze-Fracture Study on Choriocapillaries in Spontaneously Hypertensive Rats

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          Abstract

          Ultrastructural features of the choriocapillaries of spontaneously hypertensive rats (SHR) were studied by the electron microscope utilizing the freeze-fracture method. Following electron microscopic investigation, morphometric studies were carried out. The fenestrations were observed on the surface of the cleavage plane of the endothelial membrane of the choriocapillaries. On the cleavage plane facing Bruch’s membrane, except for the perinuclear region and the parajunctional zone, the fenestrations were densely distributed and showed a regular arrangement. There was no vesicular opening among these fenestrations. On the cleavage plane facing the scleral front, the fenestrations were fewer than on the cleavage plane facing Bruch’s membrane. Total area measured was 36 μ m<sup>2</sup>in SHR and 39 μ m<sup>2</sup>in controls. The average number of fenestrations per square unit (1 μ m<sup>2</sup>) was 35.0 ± 1.2 and 49.7 ± 3.6, in controls and SHR, respectively, and the difference was significant (p < 0.1%). The average diameter of the fenestrations was 78.8 ± 5.6 nm in SHR and it did not differ much from that in controls (76.6 ± 4.8 nm). The increase of the frequency of the fenestration in the endothelial cells in SHR reveals the increase of vascular permeability of the choriocapillary. In addition to these findings, pore-like structures as large as 0.8 μ m in diameter, were often found on the endothelial cells of the choriocapillaries of SHR. This structure may be considered to be evidence of a pathological increase of the vascular permeability in SHR

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1979
          1979
          03 December 2009
          : 11
          : 3-4
          : 177-191
          Affiliations
          Department of Ophthalmology, Hirosaki University School of Medicine (Director: Prof. S. Matsuyama), Hirosaki
          Article
          265004 Ophthalmic Res 1979;11:177–191
          10.1159/000265004
          89eae3ca-6c5b-4a74-a8c9-70360838b2e8
          © 1979 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 06 April 1978
          : 30 April 1979
          Page count
          Pages: 15
          Categories
          Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Freeze-fracture,Spontaneously hypertensive rats,Permeability and hypertension,Fenestration,Choriocapillary

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