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      Autophagy attenuates noise-induced hearing loss by reducing oxidative stress.

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          Abstract

          Reactive oxygen species play a dual role in mediating both cell stress and defense pathways. Here, we used pharmacological manipulations and siRNA silencing to investigate the relationship between autophagy and oxidative stress under conditions of noise-induced temporary, permanent, and severe permanent auditory threshold shifts (temporary threshold shift [TTS], permanent threshold shift [PTS], and severe PTS [sPTS], respectively) in adult CBA/J mice.

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          Author and article information

          Journal
          Antioxid. Redox Signal.
          Antioxidants & redox signaling
          Mary Ann Liebert Inc
          1557-7716
          1523-0864
          May 20 2015
          : 22
          : 15
          Affiliations
          [1 ] 1 Department of Pathology and Laboratory Medicine, Medical University of South Carolina , Charleston, South Carolina.
          Article
          10.1089/ars.2014.6004
          4410759
          25694169

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