Genome-wide transcriptomic alterations induced by ethanol treatment in human dental pulp stem cells (DPSCs)

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Abstract

Human dental pulp stem cells (DPSCs) isolated from adult dental pulp are multipotent mesenchymal stem cells that can be directed to differentiate into osteogenic/odontogenic cells and also trans-differentiate into neuronal cells. The utility of DPSC has been explored in odontogenic differentiation for tooth regeneration. Alcohol abuse appears to lead to periodontal disease, tooth decay and mouth sores that are potentially precancerous. Persons who abuse alcohol are at high risk of having seriously deteriorated teeth, gums and compromised oral health in general. It is currently unknown if alcohol exposure has any impact on adult stem cell maintenance, stem cell fate determination and plasticity, and stem cell niche environment. Here we provide detailed experimental methods, analysis and information associated with our data deposited into Gene Expression Omnibus (GEO) under GSE57255. Our data provide transcriptomic changes that are occurring by EtOH treatment of DPSCs at 24-hour and 48-hour time point.

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Author and article information

Contributors

Yong Kim

Journal

Journal ID (nlm-ta): Genom Data

Journal ID (iso-abbrev): Genom Data

Title: Genomics Data

Publisher: Elsevier

ISSN (Electronic): 2213-5960

Publication date PMC-release: 20 June 2014

Publication date Collection: December 2014

Publication date (Electronic): 20 June 2014

Volume: 2

Pages: 127-131

Affiliations

[a ]Laboratory of Stem Cell and Cancer Epigenetic Research, UCLA School of Dentistry, Los Angeles, CA, USA

[b ]Department of Biostatistics, UCLA School of Public Health, Los Angeles, CA, USA

[c ]Center for Oral and Head/Neck Oncology Research Center, Los Angeles, CA, USA

[d ]Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA, USA

[e ]UCLA's Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA

[f ]UCLA Broad Stem Cell Research Center, Los Angeles, CA, USA

Author notes

[* ]Corresponding author at: Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA, USA. thadyk@ 123456ucla.edu

[1]

Equal contribution.

[2]

Present address: The Children's Hospital of Orange County Research Institute, Orange, CA, USA.

[3]

Present address: Dr. Anthony Volpe Research Center, American Dental Association Foundation, Gaithersburg, MD, USA.

Article

Publisher ID: S2213-5960(14)00044-0

DOI: 10.1016/j.gdata.2014.06.011

PMC ID: 4101542

PubMed ID: 25045622

SO-VID: 89f8cc16-7545-4a60-93c8-88d85004c1aa

License:

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

History

Date received : 27 May 2014

Date revision received : 10 June 2014

Date accepted : 11 June 2014

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