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      Effect of Bromocriptine on Secretion and Morphology of Human Prolactin Cell Adenomas in vitro

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          Abstract

          The direct effect of short-term bromocriptine administration on human prolactin cell adenomas in vitro was studied by light and electron microscopy and correlated with the effect on hormone release. The light microscopic and, for the first time, ultrastructural characteristics of adenomatous prolactin cells in control and treated cultures were analyzed morphometrically and the changes induced by bromocriptine were quantified. Following 72 h treatment which lowered levels of prolactin release, there was a marked reduction in cell size, cytoplasmic volume and cytoplasmic volume densities of endoplasmic reticulum and Golgi apparatus. In contrast, the percentage of cytoplasm occupied by lysosomes increased. There was no consistent change in number and diameter of secretory granules. These findings indicate that prolactin cell involution is a direct effect of bromocriptine and suggest that reduction in endoplasmic reticulum and Golgi complex is largely responsible for the decreased cell size. Lysosomal degradation of cytoplasmic components may play a role in this process.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1988
          1988
          02 December 2008
          : 30
          : 1
          : 32-38
          Affiliations
          aDepartment of Pathology, St. Michael’s Hospital, University of Toronto, Ont., Canada; bUniversity of Glasgow Medical School, Glasgow, UK
          Article
          181023 Horm Res 1988;30:32–38
          10.1159/000181023
          3220463
          © 1988 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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