+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Urinary Growth Hormone Excretion in 657 Healthy Children and Adults: Normal Values, Inter- and Intraindividual Variations

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Urinary growth hormone (u-GH) excretion was measured in 547 healthy children and 110 adults by ELISA with a detection limit of 1.1 ng/l u-GH after prior concentration of the urine samples (20- to 30-fold). u-GH excretion values were significantly dependent on the pubertal stage (p < 0.0001) with maximum values in Tanner stage 3 for girls and 4 for boys. This corresponded to a peak in u-GH excretion between 11.5–14.5 years in girls and 12.5–16 years in boys. Additionally, u-GH excretion in adults was significantly higher than in prepubertal children (p < 0.001). The day/night ratio of u-GH excretion (pg/h) was significantly higher in females than in males (p < 0.01). In Tanner stages 1–4, u-GH excretion during the day was lower than that at night, whereas the opposite was true in late puberty and in adult women. The interindividual variation of u-GH excretion within the same Tanner stage was considerable and approximately double the intraindividual variation. The day-to-day variation could be further reduced by collection of three consecutive urine samples. The variations were larger if night samples instead of 24-hour samples were considered. The expression of u-GH excretion in nanograms per gram creatinine did not diminish the observed variation and blunted the pubertal increase in u-GH excretion. In conclusion, (1) u-GH excretion depends significantly on age, sex and pubertal maturation as does the day/night ratio of u-GH excretion. (2) The intraindividual variation in u-GH excretion is considerable. In contrast, the interindividual variation is only half as large and can be further reduced by consecutive samples. (3) It is of no advantage to relate u-GH excretion to creatinine output. Thus, we recommend that reference intervals for u-GH excretion be expressed in nano- or picograms per period. They should be based on a large number of healthy volunteers of both sexes and on either 24-hour or on several overnight urine collections.

          Related collections

          Author and article information

          Hormone Research in Paediatrics
          S. Karger AG
          02 December 2008
          : 36
          : 5-6
          : 174-182
          aUniversity Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark; bUniversity Department of Clinical Chemistry, Hvidovre Hospital, Denmark; cMedical Department/Statistics, Biopharmaceuticals Division, Novo Nordisk A/S, Gentofte, Denmark
          182156 Horm Res 1991;36:174–182
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Original Paper


          Comment on this article