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      Regulation of DNA repair throughout the cell cycle.

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          Abstract

          The repair of DNA lesions that occur endogenously or in response to diverse genotoxic stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways that regulate specific DNA-repair mechanisms in the different phases of the cell cycle. Checkpoint-arrested cells resume cell-cycle progression once damage has been repaired, whereas cells with unrepairable DNA lesions undergo permanent cell-cycle arrest or apoptosis. Recent studies have provided insights into the mechanisms that contribute to DNA repair in specific cell-cycle phases and have highlighted the mechanisms that ensure cell-cycle progression or arrest in normal and cancerous cells.

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          Author and article information

          Journal
          Nat Rev Mol Cell Biol
          Nature reviews. Molecular cell biology
          Springer Science and Business Media LLC
          1471-0080
          1471-0072
          Apr 2008
          : 9
          : 4
          Affiliations
          [1 ] FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy. dana.branzei@ifom-ieo-campus.it.
          Article
          nrm2351
          10.1038/nrm2351
          18285803
          8a16118d-55b7-4e8c-80c0-a22439eaaf4b
          History

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