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TRP channels as cellular sensors.

Nature

TRPC Cation Channels, Signal Transduction, Models, Biological, Ion Channel Gating, Humans, metabolism, Cells, genetics, chemistry, Calcium Channels, Calcium, Animals

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      Abstract

      TRP channels are the vanguard of our sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than classical sensory transduction. They are an ancient sensory apparatus for the cell, not just the multicellular organism, and they have been adapted to respond to all manner of stimuli, from both within and outside the cell.

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      Journal
      10.1038/nature02196
      14654832

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