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      Coding of facial expressions of pain in the laboratory mouse

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          Abstract

          Facial expression is widely used as a measure of pain in infants; whether nonhuman animals display such pain expressions has never been systematically assessed. We developed the mouse grimace scale (MGS), a standardized behavioral coding system with high accuracy and reliability; assays involving noxious stimuli of moderate duration are accompanied by facial expressions of pain. This measure of spontaneously emitted pain may provide insight into the subjective pain experience of mice.

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          Most cited references 29

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          Intraclass correlations: Uses in assessing rater reliability.

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            Quantitative assessment of tactile allodynia in the rat paw

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              The expression of the emotions in man and animals.

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                Author and article information

                Journal
                Nature Methods
                Nat Methods
                Springer Science and Business Media LLC
                1548-7091
                1548-7105
                June 2010
                May 9 2010
                June 2010
                : 7
                : 6
                : 447-449
                Article
                10.1038/nmeth.1455
                20453868
                © 2010

                http://www.springer.com/tdm

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