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Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.
Alan R Shuldiner
1 ,
Jeffrey R O'Connell ,
Kevin P Bliden ,
Amish Gandhi ,
Kathleen Ryan ,
Richard B Horenstein ,
Coleen M Damcott ,
Ruth Pakyz ,
Udaya S Tantry ,
Quince Gibson ,
Toni I Pollin ,
Wendy Post ,
Afshin Parsa ,
Braxton D Mitchell ,
Nauder Faraday ,
William Herzog ,
Paul A Gurbel
Aug 26 2009
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Abstract
Clopidogrel therapy improves cardiovascular outcomes in patients with acute coronary syndromes and following percutaneous coronary intervention by inhibiting adenosine diphosphate (ADP)-dependent platelet activation. However, nonresponsiveness is widely recognized and is related to recurrent ischemic events.