The First Case of Eruptive Pyogenic Granuloma following COVID-19 Vaccination

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Abstract

Introduction

Pyogenic granuloma presents clinically as a rapidly growing, friable, red papule of skin or mucosa, commonly measuring less than 10 mm with frequent bleeding due to ulceration. Angioproliferative diseases including pyogenic granuloma and cherry angioma have been reported during COVID-19 infection or following COVID-19 vaccination.

Case Presentation

Here, we report a 52-year-old female patient who developed diffuse skin eruptions 3 weeks after the second dose of COVID-19 vaccination.

Conclusion

As per our knowledge, this is the first case of eruptive PG following COVID-19 vaccination. Oral propranolol and PDL laser therapy were administered after obtaining inconvenient results from electro-cautery, and there was a good response within 6 weeks of starting therapy, defined by the cessation of new lesion formation and a decrease in the size of large lesions.

Related collections

Most cited references 29

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Pyogenic granuloma (lobular capillary hemangioma): a clinicopathologic study of 178 cases.

J Mulliken, K Wiss, J Patrice (1991)

Pyogenic granuloma (lobular capillary hemangioma) is a common acquired vascular lesion of the skin and mucous membranes in the pediatric age group. This is a retrospective analysis of 178 patients, 17 years of age and younger (mean age 6.7 yrs). Forty-two percent of the lesions occurred in the first five years of life; only 12% appeared in infants less than 1 year old. The male:female ratio was 3:2. Most patients (74.2%) had no history of trauma or predisposing dermatologic condition. The mean lesional size was 6.5 mm and the mean duration at diagnosis was 3.8 months. The granulomas were most commonly located in the head and neck area (62.4%), followed in order of decreasing frequency by trunk (19.7%), upper extremity (12.9%), and lower extremity (5.0%). The preponderance (88.2%) occurred on the skin, the remaining ones involved the mucous membranes of the oral cavity and conjunctivae. Histologic examination demonstrated normal numbers of mast cells, in contrast to increased mast cells characteristic of proliferative phase hemangiomas. Most lesions (n = 149) were treated by full-thickness skin excision and linear closure; there were no recurrences in this group. The recurrence rate in 23 lesions treated by shave (intradermal) excision and cautery or cautery alone was 43.5%.

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Pyogenic granuloma - the quest for optimum treatment: audit of treatment of 408 cases.

A Athanassopoulos, A. J. P. Clover, P. Budny … (2006)

Pyogenic granuloma is a common, acquired, benign vascular lesion of skin and mucous membranes which may occasionally present intravascularly or subcutaneously. Pyogenic granuloma occur in all age groups and although they may eventually regress, removal of unsightly, bleeding or uncomfortably positioned lesions is usually sought before this takes place. This is a retrospective study of 408 cases of pyogenic granuloma that were analysed by the Stoke Mandeville Histopathology laboratory between 1994 and 2004. This study was carried out to review the sex, age and anatomic distribution of the lesions and to assess the most successful form of treatment on the basis of recurrence risk and other measures such as aesthetic result, acceptability and appropriateness of the procedure with respect to the patient. There was a slight male preponderance especially among children. The exception to this was lesions on mucous membranes, which were more common in women. Head and neck was the most common anatomical location, in particular the cheek and intraoral locations. Fewest recurrences were noted following excision and direct closure although all techniques investigated showed an acceptably low recurrence rate. Whatever technique is used it must yield material for histopathological analysis to ensure the exclusion of differential diagnoses.

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Is Open Access

COVID‐19 vaccination and inflammatory skin diseases

Fabrizio Martora, Alessia Villani, Teresa Battista … (2022)

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Author and article information

Journal

Journal ID (nlm-ta): Case Rep Dermatol

Journal ID (iso-abbrev): Case Rep Dermatol

Journal ID (hwp): CDE

Journal ID (publisher-id): CDE

Title: Case Reports in Dermatology

Publisher: S. Karger AG (Basel, Switzerland )

ISSN (Electronic): 1662-6567

Publication date (Electronic): 15 July 2024

Publication date Collection: Jan-Dec 2024

Volume: 16

Issue: 1

Pages: 190-197

Affiliations

[a ]Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran

[b ]Department of Dermatopathology, Razi Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran

[c ]Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran

Author notes

Correspondence to: Zahra Razavi, zohal_z70@ 123456yahoo.com

Article

Publisher ID: 539849

DOI: 10.1159/000539849

PMC ID: 11250667

PubMed ID: 39015396

SO-VID: 8a5d3336-b9eb-4d69-b41f-afe271917154

License:

This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) ( http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.

History

Date received : 25 January 2024

Date accepted : 10 June 2024

Date: 2024

Page count

Figures: 3, Tables: 1, References: 24, Pages: 8

Funding

No funding was received.

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