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Alzheimer's disease is a synaptic failure.

Science (New York, N.Y.)

Synaptic Transmission, ultrastructure, physiology, Synapses, Presenilin-1, Mice, Transgenic, Mice, Memory, genetics, Membrane Proteins, Long-Term Potentiation, Humans, Cognition, physiopathology, pathology, Brain, Animals, metabolism, Amyloid beta-Protein Precursor, Amyloid beta-Peptides, Alzheimer Disease

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      Abstract

      In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid beta protein.

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      10.1126/science.1074069
      12399581

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