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      Left Atrial Appendage Closure as an Alternative to Warfarin for Stroke Prevention in Atrial Fibrillation: A Patient-Level Meta-Analysis.

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          Abstract

          The risk-benefit ratio of left atrial appendage closure (LAAC) versus systemic therapy (warfarin) for prevention of stroke, systemic embolism, and cardiovascular death in nonvalvular atrial fibrillation (NVAF) requires continued evaluation.

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          Journal
          Journal ID (iso-abbrev): J. Am. Coll. Cardiol.
          Title: Journal of the American College of Cardiology
          ISSN (Electronic): 1558-3597
          ISSN (Print): 0735-1097
          Publication date (Electronic): Jun 23 2015
          Volume: 65
          Issue: 24
          Affiliations
          [1 ] Mayo Clinic, Rochester, Minnesota. Electronic address: holmes.david@mayo.edu.
          [2 ] St. John's Health Center, Santa Monica, California.
          [3 ] Cedars Sinai Medical Center, Los Angeles, California.
          [4 ] Scripps Clinic, La Jolla, California.
          [5 ] Mercy Hospital, St. Louis, Missouri.
          [6 ] Cardiovascular Center Frankfurt, Sankt Katharinen, Frankfurt, Germany.
          [7 ] Methodist Hospital, Houston, Texas.
          [8 ] Mount Sinai School of Medicine, New York, New York.
          Article
          Publisher Item ID: S0735-1097(15)02023-9
          DOI: 10.1016/j.jacc.2015.04.025
          PubMed ID: 26088300
          Copyright statement: Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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          Keywords: long-term warfarin, appendage occlusion, stroke prevention, thromboembolism, warfarin alternative

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