Adenosine Receptor Adora2b Plays a Mechanistic Role in the Protective Effect of the Volatile Anesthetic Sevoflurane during Liver Ischemia/Reperfusion.

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Abstract

Liver ischemia/reperfusion (IR) injury is characterized by hepatic tissue damage and an inflammatory response. This is accompanied by the formation and vascular sequestration of platelet-neutrophil conjugates (PNCs). Signaling through Adora2b adenosine receptors can provide liver protection. Volatile anesthetics may interact with adenosine receptors. This study investigates potential antiinflammatory effects of the volatile anesthetic sevoflurane during liver IR.

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Journal

Journal ID (iso-abbrev): Anesthesiology

Title: Anesthesiology

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1528-1175

ISSN (Print): 0003-3022

Publication date (Electronic): September 2016

Volume: 125

Issue: 3

Affiliations

[1 ] From the Department of Anaesthesiology and Intensive Care Medicine, Tübingen University Hospital; Eberhard-Karls University Tübingen, Tübingen, Germany.

Article

DOI: 10.1097/ALN.0000000000001234

PubMed ID: 27404219

SO-VID: 8a6c818f-3af2-46ce-b022-9c6b589dbff2

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