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Logrank, play the winner, power and ethics.

Author(s): A Hallström, M Peckova, Ronald M. Brooks

Publication date: 1996-10-30

Keywords: Anti-Arrhythmia Agents, therapeutic use, Defibrillators, Implantable, Ethics, Medical, Humans, Models, Statistical, Patient Selection, Power (Psychology), Randomized Controlled Trials as Topic, methods, Survival Analysis, Tachycardia, Ventricular, mortality, therapy

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Abstract

We show by simulation and numerical integration techniques that power is largely unaffected by play the winner strategies in a typical chronic disease mortality trial utilizing the logrank test. This raises the issue of the ethics of equal allocation in such a setting.

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PubMed ID:: 8910958

DOI:: 10.1002/(SICI)1097-0258(19961030)15:20<2135::AID-SIM355>3.0.CO;2-G

ScienceOpen disciplines: Chemistry

Keywords: Anti-Arrhythmia Agents,therapeutic use,Defibrillators, Implantable,Ethics, Medical,Humans,Models, Statistical,Patient Selection,Power (Psychology),Randomized Controlled Trials as Topic,methods,Survival Analysis,Tachycardia, Ventricular,mortality,therapy

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ScienceOpen disciplines: Chemistry

Logrank, play the winner, power and ethics.

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