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      Attenuated cold sensitivity in TRPM8 null mice.

      Neuron

      Analysis of Variance, Animals, Behavior, Animal, drug effects, Calcium, metabolism, Capsaicin, pharmacology, Cells, Cultured, Cold Temperature, Ganglia, Spinal, cytology, Inflammation, chemically induced, genetics, physiopathology, Methanol, Mice, Mice, Inbred C57BL, Mice, Knockout, physiology, Motor Activity, Neurons, Afferent, Pain Measurement, methods, Pyrimidinones, Reaction Time, TRPM Cation Channels, deficiency, Thermosensing

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          Abstract

          Thermosensation is an essential sensory function that is subserved by a variety of transducer molecules, including those from the Transient Receptor Potential (TRP) ion channel superfamily. One of its members, TRPM8 (CMR1), a ligand-gated, nonselective cation channel, is activated by both cold and chemical stimuli in vitro. However, its roles in cold thermosensation and pain in vivo have not been fully elucidated. Here, we show that sensory neurons derived from TRPM8 null mice lack detectable levels of TRPM8 mRNA and protein and that the number of these neurons responding to cold (18 degrees C) and menthol (100 microM) is greatly decreased. Furthermore, compared with WT mice, TRPM8 null mice display deficiencies in certain behaviors, including icilin-induced jumping and cold sensation, as well as a significant reduction in injury-induced responsiveness to acetone cooling. These results suggest that TRPM8 may play an important role in certain types of cold-induced pain in humans.

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          Journal
          17481392
          10.1016/j.neuron.2007.04.017

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