Aberrant Dynamic Functional Connectivity of Posterior Cingulate Cortex Subregions in Major Depressive Disorder With Suicidal Ideation

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Abstract

Accumulating evidence indicates the presence of structural and functional abnormalities of the posterior cingulate cortex (PCC) in patients with major depressive disorder (MDD) with suicidal ideation (SI). Nevertheless, the subregional-level dynamic functional connectivity (dFC) of the PCC has not been investigated in MDD with SI. We therefore sought to investigate the presence of aberrant dFC variability in PCC subregions in MDD patients with SI. We analyzed resting-state functional magnetic resonance imaging (fMRI) data from 31 unmedicated MDD patients with SI (SI group), 56 unmedicated MDD patients without SI (NSI group), and 48 matched healthy control (HC) subjects. The sliding-window method was applied to characterize the whole-brain dFC of each PCC subregion [the ventral PCC (vPCC) and dorsal PCC (dPCC)]. In addition, we evaluated associations between clinical variables and the aberrant dFC variability of those brain regions showing significant between-group differences. Compared with HCS, the SI and the NSI groups exhibited higher dFC variability between the left dPCC and left fusiform gyrus and between the right vPCC and left inferior frontal gyrus (IFG). The SI group showed higher dFC variability between the left vPCC and left IFG than the NSI group. Furthermore, the dFC variability between the left vPCC and left IFG was positively correlated with Scale for Suicidal Ideation (SSI) score in patients with MDD (i.e., the SI and NSI groups). Our results indicate that aberrant dFC variability between the vPCC and IFG might provide a neural-network explanation for SI and may provide a potential target for future therapeutic interventions in MDD patients with SI.

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Author and article information

Contributors

Weicheng Li: URI : http://loop.frontiersin.org/people/1629267/overview

Xiaofeng Lan: URI : http://loop.frontiersin.org/people/1579442/overview

Kai Wu: URI : http://loop.frontiersin.org/people/71591/overview

Guohui Lao: URI : http://loop.frontiersin.org/people/689812/overview

Guixiang Li: URI : http://loop.frontiersin.org/people/1136557/overview

Yanling Zhou: URI : http://loop.frontiersin.org/people/959943/overview

Yuping Ning: URI : http://loop.frontiersin.org/people/406575/overview

Journal

Journal ID (nlm-ta): Front Neurosci

Journal ID (iso-abbrev): Front Neurosci

Journal ID (publisher-id): Front. Neurosci.

Title: Frontiers in Neuroscience

Publisher: Frontiers Media S.A.

ISSN (Print): 1662-4548

ISSN (Electronic): 1662-453X

Publication date (Electronic): 19 July 2022

Publication date Collection: 2022

Volume: 16

Electronic Location Identifier: 937145

Affiliations

[1] ¹The Affiliated Brain Hospital of Guangzhou Medical University , Guangzhou, China

[2] ²The First School of Clinical Medicine, Southern Medical University , Guangzhou, China

[3] ³Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders , Guangzhou, China

[4] ⁴School of Biomedical Sciences and Engineering, South China University of Technology , Guangzhou, China

[5] ⁵Guangdong Institute of Medical Instruments , Guangzhou, China

[6] ⁶Institute of Biological and Medical Engineering, Guangdong Academy of Sciences , Guangzhou, China

Author notes

Edited by: Zaixu Cui, Chinese Institute for Brain Research (CIBR), China

Reviewed by: Xia Liang, Harbin Institute of Technology, China; Shaoling Peng, Beijing Normal University, China

*Correspondence: Yanling Zhou, zhouylivy@ 123456aliyun.com

Yuping Ning, ningjeny@ 123456126.com

This article was submitted to Brain Imaging Methods, a section of the journal Frontiers in Neuroscience

Article

DOI: 10.3389/fnins.2022.937145

PMC ID: 9344055

PubMed ID: 35928017

SO-VID: 8aa9e1a2-f420-44b6-a91c-75779bf22b2b

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

History

Date received : 05 May 2022

Date accepted : 17 June 2022

Page count

Figures: 4, Tables: 2, Equations: 0, References: 67, Pages: 10, Words: 7567

Funding

Funded by: National Natural Science Foundation of China, doi 10.13039/501100001809;

Aberrant Dynamic Functional Connectivity of Posterior Cingulate Cortex Subregions in Major Depressive Disorder With Suicidal Ideation

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Karger: Neurology and Neuroscience

Most cited references 67

The brain's default network: anatomy, function, and relevance to disease.

Control of goal-directed and stimulus-driven attention in the brain.

Improved optimization for the robust and accurate linear registration and motion correction of brain images.

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