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Pesticides and Parkinson's disease
April 1999
April 1999
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Abstract
Epidemiological studies and case reports provide evidence for an association between
Parkinson's disease and past exposure to pesticides. Susceptibility to the effects
of pesticides and other putative neurotoxins depends on variability in xenobiotic
metabolism possibly generated by genetic polymorphisms, aging and variation in exposure
to environmental agents including pesticides. The simplest mechanistic hypothesis
for the association of pesticides with Parkinson's disease is that pesticides or their
metabolites are directly toxic to mitochondria, although modulation of xenobiotic
metabolism by pesticides provides an adjunct or alternative hypothesis.