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      Retromer

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      Current Opinion in Cell Biology
      Elsevier BV

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          Abstract

          The retromer is a heteropentameric complex that associates with the cytosolic face of endosomes and mediates retrograde transport of transmembrane cargo from endosomes to the trans-Golgi network. The mammalian retromer complex comprises a sorting nexin dimer composed of a still undefined combination of SNX1, SNX2, SNX5 and SNX6, and a cargo-recognition trimer composed of Vps26, Vps29 and Vps35. The SNX subunits contain PX and BAR domains that allow binding to PI(3)P enriched, highly curved membranes of endosomal vesicles and tubules, while Vps26, Vps29 and Vps35 have arrestin, phosphoesterase and alpha-solenoid folds, respectively. Recent studies have implicated retromer in a broad range of physiological, developmental and pathological processes, underscoring the critical nature of retrograde transport mediated by this complex.

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          Author and article information

          Journal
          Current Opinion in Cell Biology
          Current Opinion in Cell Biology
          Elsevier BV
          09550674
          August 2008
          August 2008
          : 20
          : 4
          : 427-436
          Article
          10.1016/j.ceb.2008.03.009
          2833274
          18472259
          8aade165-6ef3-4cbb-a974-b547b2418f30
          © 2008

          https://www.elsevier.com/tdm/userlicense/1.0/

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