EIF1AX Mutation in a Patient with Hürthle Cell Carcinoma.

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Abstract

The EIF1AX gene is a novel cancer gene that has been reported in the tumorigenesis of papillary thyroid carcinoma, follicular variant papillary thyroid carcinoma, and anaplastic thyroid carcinoma. A 71-year-old woman presented with a right thyroid mass, which was follicular neoplasm on cytology. The fine needle aspirate of the nodule was examined by next-generation sequencing and found to harbor EIF1AX and TP53 mutations. Right thyroid lobectomy was performed with final pathology showing Hürthle cell carcinoma with capsular and vascular invasion. We report an EIF1AX mutation in a patient found to have Hürthle cell carcinoma.

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Author and article information

Journal

Journal ID (iso-abbrev): Endocr Pathol

Title: Endocrine pathology

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1559-0097

ISSN (Print): 1046-3976

Publication date (Electronic): Mar 2018

Volume: 29

Issue: 1

Affiliations

[1 ] Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, 925 Chestnut Street 6th Floor, Philadelphia, PA, 19107, USA. michael.topf@jefferson.edu.

[2 ] Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1025 Walnut Street, 401 College, Philadelphia, PA, 19107, USA.

[3 ] Department of Endocrinology, Thomas Jefferson University, 211 S 9th Street, Philadelphia, PA, USA.

[4 ] Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, 925 Chestnut Street 6th Floor, Philadelphia, PA, 19107, USA.

Article

Publisher Item ID: 10.1007/s12022-017-9501-8

DOI: 10.1007/s12022-017-9501-8

PubMed ID: 28965201

SO-VID: 8aae6d38-60f6-470b-8efa-b243474bf192

History

Keywords: EIF1AX,FNA,Hürthle cell carcinoma,TP53,Thyroid

Data availability:

Keywords: EIF1AX, FNA, Hürthle cell carcinoma, TP53, Thyroid

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