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Expression of c-kit (CD117) and Ki67 provides information about the possible cell of origin and clinical course of gastrointestinal stromal tumours.
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Abstract
Gastrointestinal stromal tumours (GIST) were analysed to determine their immunophenotype with emphasis on the expression of CD34 and c-kit and to identify a possible cell of origin. Furthermore, the aim was to correlate clinical, histological and immunophenotypic parameters to their clinical course by means of statistical analysis.