Human Urinary Fluoride Excretion as Influenced by Renal Functional Impairment

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Abstract

The effects of renal function on human renal fluoride (F-) excretion and serum F<sub>-</sub> concentrations were studied in subjects with normal renal function, in patients with variable degrees of renal insufficiency and in patients undergoing regular hemodialysis treatment. The mechanisms of human renal F- excretion include glomerular filtration and tubular reabsorption. Patients suffering from chronic renal disease tend to continue to excrete normal dietary loads of F- until the creatinine clearance decreases below 25 ml/min. In chronic renal failure elevation of the serum fluoride concentration is delayed and less than might be expected from impairment of the glomerular filtration rate, because tubular reabsorption diminishes presumably due to expansion of the extracellular fluid compartiment.

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1980

Publication date (Print): 1980

Publication date (Electronic): 02 December 2008

Volume: 26

Issue: 2

Pages: 69-72

Affiliations

Section of Nephrology, University Hospital of Zürich, Zürich

Article

Publisher ID: 181954 Other ID: Nephron 1980;26:69–72

DOI: 10.1159/000181954

PubMed ID: 7412962

SO-VID: 8aea0c11-d676-4fd0-bbd0-f63f114a23b7

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 14 January 1980

Page count

Pages: 4

Product

Self URI (application/pdf): https://www.karger.com/Article/Pdf/181954

Self URI (text/html): https://www.karger.com/Article/FullText/181954

Self URI (journal page): https://www.karger.com/SubjectArea/Nephrology

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