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      Measurement of Vitamin D Metabolites in Anephric Subjects

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          Abstract

          Circulating concentrations of 1,25-dihydroxyvitamin D, 24,25-dihydroxyvitamin D and 25-hydroxyvitamin D were measured in 21 anephric subjects. 13 subjects had no therapy with vitamin D, dihydrotachysterol or lα-hydroxyvitamin D<sub>3</sub>. In 7 subjects of this group 1,25-dihydroxyvitamin D was undetectable ( < 5 pmol/l). In the other 6 patients concentrations ranged from 10 to 43 pmol/l (reference value 111 ± 33 pmol/l). All subjects taking high doses of vitamin D showed detectable 1,25-dihydroxyvitamin D concentrations in the same range. Dihydrotachysterol therapy caused spuriously high ‘1,25-dihydroxyvitamin D’ values, probably by interference of a metabolite of dihydrotachysterol in our assay. In subjects on vitamin D or dihydrotachysterol therapy 25-hydroxyvitamin D concentrations were significantly elevated (314 ± 146 nmol/l and 98 ± 19 nmol/l, respectively; reference value 52 ± 22 nmol/l). Concentrations of 24,25-dihydroxyvitamin D were only measured in subjects without vitamin D<sub>2</sub> intake. In general very low but detectable concentrations were found. One subject on a high dose of vitamin D<sub>3</sub> showed a 24,25-dihydroxyvitamin D<sub>3</sub> concentration of 10.2 nmol/l (reference value 4.4 ± 2.9 nmol/l). Our results therefore confirm earlier reports on extrarenal synthesis of 24,25-dihydroxyvitamin D and suggest that there may be extrarenal production of 1,25-dihydroxyvitamin D as well.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1984
          1984
          03 December 2008
          : 36
          : 4
          : 230-234
          Affiliations
          Department of Internal Medicine, Research Laboratory, Academisch Ziekenhuis der Vrije Universiteit, De Boelelaan 1117, Amsterdam, The Netherlands
          Article
          183159 Nephron 1984;36:230–234
          10.1159/000183159
          6608697
          © 1984 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

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