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      Two Possible Mechanisms for Precocious Puberty Induced in Female Rats by Pituitary Grafts

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          Abstract

          Many reports indicate that prolactin has a role in puberty occurrence. The present study was developed to evaluate the action of pituitary grafts on puberty. Female rats grafted on day 21 with ‘adult’ (90 days old) or ‘young’ (21 days old) pituitaries showed precocious vaginal opening and first estrus. The puberty advancement induced by ‘adult’ transplants was due to an increase in plasma prolactin values and can be blocked by bromocriptine treatment. The puberty advancement induced by ‘young’ transplants was not associated with increased prolactin levels and cannot be blocked by bromocriptine. These results suggest the existence of two possible mechanisms in precocious puberty induced by pituitary grafts: a prolactin-dependent one and another one not directly related with prolactin.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1986
          1986
          01 April 2008
          : 42
          : 4
          : 323-327
          Affiliations
          Department of Physiology, Faculty of Medicine, University of Córdoba, Spain
          Article
          124458 Neuroendocrinology 1986;42:323–327
          10.1159/000124458
          3960275
          © 1986 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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