130
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system.

      Cell

      Animals, Bacteroides fragilis, immunology, pathogenicity, CD4-Positive T-Lymphocytes, drug effects, Cell Proliferation, Cytokines, biosynthesis, Dendritic Cells, Immune System, growth & development, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Polysaccharides, Bacterial, pharmacology, Symbiosis

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The mammalian gastrointestinal tract harbors a complex ecosystem consisting of countless bacteria in homeostasis with the host immune system. Shaped by evolution, this partnership has potential for symbiotic benefit. However, the identities of bacterial molecules mediating symbiosis remain undefined. Here we show that, during colonization of animals with the ubiquitous gut microorganism Bacteroides fragilis, a bacterial polysaccharide (PSA) directs the cellular and physical maturation of the developing immune system. Comparison with germ-free animals reveals that the immunomodulatory activities of PSA during B. fragilis colonization include correcting systemic T cell deficiencies and T(H)1/T(H)2 imbalances and directing lymphoid organogenesis. A PSA mutant of B. fragilis does not restore these immunologic functions. PSA presented by intestinal dendritic cells activates CD4+ T cells and elicits appropriate cytokine production. These findings provide a molecular basis for host-bacterial symbiosis and reveal the archetypal molecule of commensal bacteria that mediates development of the host immune system.

          Related collections

          Author and article information

          Journal
          16009137
          10.1016/j.cell.2005.05.007

          Comments

          Comment on this article