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Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride) mixtures for wound care applications

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      Abstract

      Novel antimicrobial hydrogels with good mechanical and physical properties were synthesized by autoclaving aqueous mixtures of poly(vinyl alcohol) and poly(methyl vinyl ether- alt-maleic anhydride).

      Abstract

      Novel antimicrobial hydrogels with good mechanical and physical properties were synthesized by autoclaving aqueous mixtures of poly(vinyl alcohol) and poly(methyl vinyl ether- alt-maleic anhydride). The structure of these materials was studied by infrared spectroscopy, scanning electron microscopy and solid state nuclear magnetic resonance. The swelling behavior, mechanical properties and adhesion of the hydrogels to porcine skin were evaluated. It was established that these hydrogels exhibited antimicrobial properties and inhibited bacteria growth against Staphylococcus aureus. The biocompatibility of the hydrogels was confirmed using an MTT assay (indirect cytotoxicity) and by monitoring cell proliferation in contact with the gels (direct cytotoxicity).

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      Most cited references 37

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        Hydrogels in drug delivery: Progress and challenges

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          Wound healing dressings and drug delivery systems: a review.

          The variety of wound types has resulted in a wide range of wound dressings with new products frequently introduced to target different aspects of the wound healing process. The ideal dressing should achieve rapid healing at reasonable cost with minimal inconvenience to the patient. This article offers a review of the common wound management dressings and emerging technologies for achieving improved wound healing. It also reviews many of the dressings and novel polymers used for the delivery of drugs to acute, chronic and other types of wound. These include hydrocolloids, alginates, hydrogels, polyurethane, collagen, chitosan, pectin and hyaluronic acid. There is also a brief section on the use of biological polymers as tissue engineered scaffolds and skin grafts. Pharmacological agents such as antibiotics, vitamins, minerals, growth factors and other wound healing accelerators that take active part in the healing process are discussed. Direct delivery of these agents to the wound site is desirable, particularly when systemic delivery could cause organ damage due to toxicological concerns associated with the preferred agents. This review concerns the requirement for formulations with improved properties for effective and accurate delivery of the required therapeutic agents. General formulation approaches towards achieving optimum physical properties and controlled delivery characteristics for an active wound healing dosage form are also considered briefly.
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            Author and article information

            Affiliations
            [1 ]Reading School of Pharmacy
            [2 ]University of Reading
            [3 ]Berkshire
            [4 ]UK
            [5 ]Institute of Polymer Science and Technology
            [6 ]CSIC
            [7 ]Madrid 28006
            [8 ]Spain
            [9 ]CIBER-BBN
            [10 ]ConvaTec UK Ltd
            [11 ]Flintshire CH5 2NU
            Journal
            RSCACL
            RSC Advances
            RSC Adv.
            Royal Society of Chemistry (RSC)
            2046-2069
            2016
            2016
            : 6
            : 60
            : 55211-55219
            10.1039/C6RA08234C
            © 2016
            Product
            Self URI (article page): http://xlink.rsc.org/?DOI=C6RA08234C

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