Modafinil and cognitive enhancement in schizophrenia and healthy volunteers: the effects of test battery in a randomised controlled trial.

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Abstract

Cognitive deficits in schizophrenia have major functional impacts. Modafinil is a cognitive enhancer whose effect in healthy volunteers is well-described, but whose effects on the cognitive deficits of schizophrenia appear to be inconsistent. Two possible reasons for this are that cognitive test batteries vary in their sensitivity, or that the phase of illness may be important, with patients early in their illness responding better.

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Author and article information

Journal

Journal ID (iso-abbrev): Psychol Med

Title: Psychological medicine

Publisher: Cambridge University Press (CUP)

ISSN (Electronic): 1469-8978

ISSN (Print): 0033-2917

Publication date (Electronic): May 03 2017

Affiliations

[1 ] Division of Psychology & Mental Health,School of Health Sciences, University of Manchester, Manchester Academic Health Science Centre,Manchester,UK.

[2 ] Institute of Psychiatry,Psychology and Neuroscience,King's Health Partners,London,UK.

[3 ] Division of Population Health,Health Services Research & Primary Care, School of Health Sciences, University of Manchester, Manchester Academic Health Science Centre,Manchester,UK.

[4 ] Janssen Research & Development, LLC,New Brunswick,New Jersey,USA.

Article

Publisher Item ID: S0033291717000885

DOI: 10.1017/S0033291717000885

PubMed ID: 28464963

SO-VID: 8b01a239-0288-4490-9cf6-b5cb482617ae

History

Keywords: CANTAB,MATRICS MCCB,cognition,modafinil,schizophrenia

Data availability:

Keywords: CANTAB, MATRICS MCCB, cognition, modafinil, schizophrenia

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