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      IsoformSwitchAnalyzeR: Analysis of changes in genome-wide patterns of alternative splicing and its functional consequences

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      bioRxiv

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          Abstract

          Alternative splicing is an important mechanism involved in both health and disease. Recent work highlights the importance of investigating genome-wide changes in patters of splicing and the subsequent functional consequences. Unfortunately current computational methods only support such analysis on a gene-by-gene basis. To fill this gap, we extended IsoformSwitchAnalyzeR thereby enabling analysis of genome-wide changes in both specific types of alternative splicing as well as the predicted functional consequences of the resulting isoform switches. As a case study, we analyzed RNA-seq data from The Cancer Genome Atlas and found systematic changes in both alternative splicing and the consequences of the associated isoform switches.

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          Author and article information

          Journal
          bioRxiv
          August 28 2018
          Article
          10.1101/399642
          8b0b783a-8755-4544-a4d3-a642f5d22d82
          © 2018
          History

          Quantitative & Systems biology,Biophysics
          Quantitative & Systems biology, Biophysics

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