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      Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

      , , , , ,
      Cancer Cell
      Elsevier BV

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          Abstract

          Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple systemic pathophysiological processes, such as coagulation, vascular leakiness, and reprogramming of stromal recipient cells to support pre-metastatic niche formation and subsequent metastasis. Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.

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          Author and article information

          Journal
          Cancer Cell
          Cancer Cell
          Elsevier BV
          15356108
          December 2016
          December 2016
          : 30
          : 6
          : 836-848
          Article
          10.1016/j.ccell.2016.10.009
          5157696
          27960084
          8b282a85-c3b8-4b40-bc67-44b1873eec22
          © 2016

          https://www.elsevier.com/tdm/userlicense/1.0/

          http://www.elsevier.com/open-access/userlicense/1.0/

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