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      Defensins: antimicrobial peptides of innate immunity.

      1
      Nature reviews. Immunology
      Springer Science and Business Media LLC

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          Abstract

          The production of natural antibiotic peptides has emerged as an important mechanism of innate immunity in plants and animals. Defensins are diverse members of a large family of antimicrobial peptides, contributing to the antimicrobial action of granulocytes, mucosal host defence in the small intestine and epithelial host defence in the skin and elsewhere. This review, inspired by a spate of recent studies of defensins in human diseases and animal models, focuses on the biological function of defensins.

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          Author and article information

          Journal
          Nat Rev Immunol
          Nature reviews. Immunology
          Springer Science and Business Media LLC
          1474-1733
          1474-1733
          Sep 2003
          : 3
          : 9
          Affiliations
          [1 ] Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095-1690, USA. tganz@mednet.ucla.edu
          Article
          nri1180
          10.1038/nri1180
          12949495
          8b34bec0-6e78-4802-af2b-436dca48192f
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