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      The Effect of Long Term High Dose Heparin Treatment on the Course of Chronic Proliferative Glomerulonephritis

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          Abstract

          18 patients with biopsy proven chronic proliferative glomerulonephritis have been studied, 10 of the 18 received daily subcutaneous injections of depo-heparin until death or for a period of at least 1 year. 8 of the 10 patients so treated demonstrated significant improvement in renal function as measured by serial determination of endogenous creatinine clearance, Addis count, protein permeability index, and renal biopsy. 1 patient with severely impaired function prior to heparin therapy did not improve, but renal function remained stable during the period of treatment. 8 of the 10 control patients were followed adequately for evaluation. Of these 8, 6 demonstrated progressive diminution of renal function, 4 expired in renal failure; in addition, 1 control patient followed too sporadically to include in the study is known to have died of renal failure.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1971
          1971
          26 November 2008
          : 8
          : 1
          : 67-80
          Affiliations
          Departments of Medicine and Pathology, University of Florida Medical School, Gainesville, Fla.
          Article
          179907 Nephron 1971;8:67–80
          10.1159/000179907
          5155601
          © 1971 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 14
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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