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Rapid molecular detection of tuberculosis and rifampin resistance.
Catharina C Boehme
1 ,
Pamela Nabeta ,
Doris Hillemann ,
Mark P Nicol ,
Shubhada Shenai ,
Fiorella Krapp ,
Jenny Allen ,
Rasim Tahirli ,
Robert Blakemore ,
Roxana Rustomjee ,
Ana Milovic ,
Martin Jones ,
Sean M O'Brien ,
David H Persing ,
Sabine Ruesch-Gerdes ,
Eduardo Gotuzzo ,
Camilla Rodrigues ,
David Alland ,
Mark D Perkins
Sep 09 2010
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Abstract
Global control of tuberculosis is hampered by slow, insensitive diagnostic methods, particularly for the detection of drug-resistant forms and in patients with human immunodeficiency virus infection. Early detection is essential to reduce the death rate and interrupt transmission, but the complexity and infrastructure needs of sensitive methods limit their accessibility and effect.