1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Maternal overnutrition impairs offspring's insulin sensitivity: A systematic review and meta‐analysis

      review-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          This systematic review and meta‐analysis aimed to investigate the association between maternal overnutrition and offspring's insulin sensitivity—following the Preferred Reporting Items for Systematic Reviews and Meta‐analyses statement. Studies published in English before April 22, 2019, were identified through searches of four medical databases. After selection, 15 studies aiming to explore the association between prepregnancy body mass index (ppBMI) or gestational weight gain (GWG) of non‐diabetic mothers and their offspring's insulin sensitivity (fasting insulin or glucose level and Homeostatic Measurement Assessment for Insulin Resistance [HOMA‐IR]) were included in the meta‐analysis. Associations of ppBMI and GWG with offspring's insulin sensitivity were analysed by pooling regression coefficients or standardized differences in means with 95% confidence intervals (CIs). Maternal ppBMI showed significant positive correlations with the level of both fasting insulin and HOMA‐IR in offspring (standardized regression coefficient for fasting insulin: 0.107, CI [0.053, 0.160], p < 0.001 and that for HOMA‐IR: 0.063, CI [0.006, 0.121], p = 0.031). However, the result of the analysis on coefficients adjusted for offspring's actual anthropometry (BMI and adiposity) was not significant. Independent from ppBMI, GWG tended to show a positive correlation with insulin level, but not after adjustment for offspring's anthropometry. Offspring of mothers with excessive GWG showed significantly higher HOMA‐IR than those of mothers with optimal GWG ( p = 0.004). Our results demonstrate that both higher ppBMI and GWG increase the risk of offspring's insulin resistance, but the effect of ppBMI on insulin sensitivity in offspring may develop as consequence of their adiposity.

          Related collections

          Most cited references53

          • Record: found
          • Abstract: not found
          • Article: not found

          Pathophysiology of the metabolic syndrome

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS): Maternal Gestational Diabetes Mellitus and Childhood Glucose Metabolism

            OBJECTIVE Whether hyperglycemia in utero less than overt diabetes is associated with altered childhood glucose metabolism is unknown. We examined associations of gestational diabetes mellitus (GDM) not confounded by treatment with childhood glycemia in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) cohort. RESEARCH DESIGN AND METHODS HAPO Follow-up Study (FUS) included 4,160 children ages 10–14 years who completed all or part of an oral glucose tolerance test (OGTT) and whose mothers had a 75-g OGTT at ∼28 weeks of gestation with blinded glucose values. The primary predictor was GDM by World Health Organization criteria. Child outcomes were impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes. Additional measures included insulin sensitivity and secretion and oral disposition index. RESULTS For mothers with GDM, 10.6% of children had IGT compared with 5.0% of children of mothers without GDM; IFG frequencies were 9.2% and 7.4%, respectively. Type 2 diabetes cases were too few for analysis. Odds ratios (95% CI) adjusted for family history of diabetes, maternal BMI, and child BMI z score were 1.09 (0.78–1.52) for IFG and 1.96 (1.41–2.73) for IGT. GDM was positively associated with child’s 30-min, 1-h, and 2-h but not fasting glucose and inversely associated with insulin sensitivity and oral disposition index (adjusted mean difference −76.3 [95% CI −130.3 to −22.4] and −0.12 [−0.17 to −0.064]), respectively, but not insulinogenic index. CONCLUSIONS Offspring exposed to untreated GDM in utero are insulin resistant with limited β-cell compensation compared with offspring of mothers without GDM. GDM is significantly and independently associated with childhood IGT.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Impact of maternal obesity on offspring obesity and cardiometabolic disease risk.

              The prevalence of obesity among pregnant women is increasing. In addition to the short-term complications of obesity during pregnancy in both mother and child, it is now recognised that maternal obesity has long-term adverse outcomes for the health of her offspring in later life. Evidence from both animal and human studies indicates that maternal obesity increases the risk for the offspring in developing obesity and altering body composition in child- and adulthood and, additionally, it also has an impact on the offspring's cardiometabolic health with dysregulation of metabolism including glucose/insulin homoeostasis, and development of hypertension and vascular dysfunction. Potential mechanisms include effects on the development and function of adipose tissue, pancreas, muscle, liver, the vasculature and the brain. Further studies are required to elucidate the mechanisms underpinning the programming of disease risk in the offspring as a consequence of maternal obesity. The ultimate aim is to identify potential targets, which may be amenable to prevention or early intervention in order to improve the health of this and future generations.
                Bookmark

                Author and article information

                Contributors
                erika.petervari@aok.pte.hu
                Journal
                Matern Child Nutr
                Matern Child Nutr
                10.1111/(ISSN)1740-8709
                MCN
                Maternal & Child Nutrition
                John Wiley and Sons Inc. (Hoboken )
                1740-8695
                1740-8709
                22 June 2020
                October 2020
                : 16
                : 4 ( doiID: 10.1111/mcn.v16.4 )
                : e13031
                Affiliations
                [ 1 ] Institute for Translational Medicine, Medical School University of Pécs Pécs Hungary
                [ 2 ] János Szentágothai Research Centre University of Pécs Pécs Hungary
                [ 3 ] Department of Thermophysiology, Institute for Translational Medicine, Medical School University of Pécs Pécs Hungary
                [ 4 ] Division of Gastroenterology, First Department of Medicine, Medical School University of Pécs Pécs Hungary
                Author notes
                [*] [* ] Correspondence

                Erika Pétervári, MD, PhD, Institute for Translational Medicine, Medical School, University of Pécs, Szigeti str 12, H‐7624, Pécs, Hungary.

                Email: erika.petervari@ 123456aok.pte.hu

                Author information
                https://orcid.org/0000-0002-3420-9940
                https://orcid.org/0000-0002-3258-6195
                https://orcid.org/0000-0003-0399-7259
                https://orcid.org/0000-0002-7035-941X
                https://orcid.org/0000-0003-2493-0571
                https://orcid.org/0000-0003-4377-9758
                https://orcid.org/0000-0001-6667-6263
                https://orcid.org/0000-0003-3658-8427
                https://orcid.org/0000-0003-4725-9047
                https://orcid.org/0000-0002-3673-8491
                Article
                MCN13031 MCN-09-19-RA-4131.R2
                10.1111/mcn.13031
                7503101
                8b52bf7a-ec2c-4697-883e-d1ac2fe59d32
                © 2020 The Authors. Maternal & Child Nutrition published by John Wiley & Sons, Ltd.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 02 October 2019
                : 17 April 2020
                : 27 April 2020
                Page count
                Figures: 6, Tables: 5, Pages: 24, Words: 13549
                Funding
                Funded by: University of Pécs , open-funder-registry 10.13039/501100009594;
                Award ID: KA‐2019‐44
                Funded by: FK124483
                Funded by: Human Resources Development Operative Programme
                Award ID: EFOP‐3.6.2‐16‐2017‐00006
                Categories
                Review Article
                Review Articles
                Custom metadata
                2.0
                October 2020
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.9.1 mode:remove_FC converted:22.09.2020

                gestational weight gain,insulin resistance,insulin sensitivity,prepregnancy bmi

                Comments

                Comment on this article